Op-brhe120231 221..222

نویسندگان

  • Michaël F. Hofer
  • Rolando Cimaz
چکیده

Elhai et al.’s [1] study evaluates the frequency of radiological cervical spine involvement in young adults with polyarticular JIA (pJIA) compared with RA patients. The authors show that about two-thirds of patients in both groups had radiographic abnormalities in the cervical spine, including anterior atlantoaxial subluxation, erosion of the odontoid process, C1 C2 arthritis and apophyseal joint arthritis. Lesions were found even in patients without clinical symptoms and their presence correlated positively with the severity of disease. The similar prevalence of structural cervical spine lesions in young adults with pJIA and RA highlights the importance of this complication for the long-term follow-up of juvenile polyarthritis. This aspect of pJIA outcome needs further study because literature on the topic is relatively scarce, in contrast to the abundant number of papers on cervical problems in RA. Another striking point of this study is the high percentage of asymptomatic patients presenting with radiological cervical lesions. Only 42% of patients without neck complaints or findings on examination had a normal cervical scan; accordingly, the authors raise the question of the frequency of systematic cervical spine radiological controls during follow-up in pJIA. According to the ILAR classification [2], polyarthritis patients with onset before the age of 16 years are divided into two different categories, depending on the result of the RF [2]. RF-negative polyarthritis corresponds to a heterogeneous group of patients with symmetrical or asymmetrical joint involvement, presence or absence of ANAs, and includes 10 12% of the JIA cases [3, 4]. The RF-positive polyarticular category is considered to be an early form of RA and represents 2 3% of JIA patients [3]. The long-term prognosis of pJIA patients can vary but outcome studies with a follow-up of at least 10 years have shown that active arthritis is still present in 39 67% of patients [5]. In particular, the latter study showed that children who did not present with a period of disease inactivity in the 5 years of disease onset had more long-term joint damage. In another study, patients with RF-positive polyarthritis or early evidence of joint damage had a higher risk of persistent active arthritis during follow-up [6]. In Elhai et al.’s [1] study, RF-positive patients represented 60% of the cohort: more than 10 times the expected frequency in normal JIA distribution, indicating an over-representation of this category. The high proportion of RF-positive patients is likely to have influenced the results of the study and could explain similar cervical spine involvement in JIA and RA patients. Interestingly, the frequency of a positive RF was similar in patients with or without cervical involvement; these data suggest that RF-negative patients had a similarly high rate of cervical spine abnormalities, which may be explained by a significantly longer duration of disease course in comparison with that in RF-positive patients (17.3 vs 9.8 years). Imaging evaluation of children with polyarthritis is usually indicated according to clinical findings, mainly in patients with joint inflammation that persists through treatment. Plain radiography is the standard imaging technique for monitoring abnormalities in peripheral joints, but there are no recommendations for timing intervals during the follow-up of JIA patients [7]. Cervical spine involvement has been described in different forms of JIA, including polyarthritis, systemic arthritis and enthesitis-related arthritis. In 2002, Laiho et al. [8] reported cervical spine structural abnormalities in 62% of 159 JIA patients, who underwent radiographic examination because of neck symptoms or as a part of a pre-operative routine. More than 80% of the patients suffered from polyarthritis, and 25% of them were RF positive. Elhai et al.’s [1] study had similar findings but the patient cohort was quite different, since two-thirds of the patients were treated with a biotherapy and half of them did not show any neck symptoms or signs. Many children and adolescents with rheumatic diseases are treated by paediatricians who are specialists in rheumatology in paediatric settings; care for young patients will be adjusted to factors related to their age, like growth, family, and school. The paediatrician will transfer the patient to an adult clinic at the end of their adolescence and will not see their long-term outcome. Transition clinics have recently been developed to offer a smooth transfer to adult care, which is essential for continuity of care. Transition clinics have another major advantage in that they highlight the outcome of JIA patients during early adulthood. The information gathered from young adult JIA patients is useful in improving the care provided to children with JIA. Elhai et al.’s [1] study shows that cervical involvement in pJIA is common and can occur even in the absence of symptoms. This finding underlines the importance for clinicians of detecting minor cervical symptoms in JIA patients. The bias of the study could be that subjects with mild disease, which can go into long-term

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تاریخ انتشار 2013